Several genes have been identified as being involved in the development of ALS, e.g., C9orf72, SOD1, FUS, TARDBP, VCP, and UBQLN2, whose encoded mutated proteins not only cause ALS but also promote immune dysfunction suggesting the contribution of immune system-driven inflammation to the ALS pathogenesis [3]. The gene discussed is UBQLN2; the disease is amyotrophic lateral sclerosis.