Exosomes are considered key mediators of neuroinflammation [26], and also in ALS, exosomes can transfer mSOD1 from astrocytes to MNs contributing to the propagation of mutated SOD1 [27] as in recipient cells, mSOD1 affects the misfolding of normal SOD1 [28]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.