PBMC (samples from patients with cervical cancer) activated with PHA also indicated that the TNFα (−308A/A) genotype demonstrated increased proliferation rates, elevated IL-4 and TGF-β, and decreased IL-2 levels [34], and it was postulated that SNPs of cytokine genes act as the potential predictors of cervical HPV infection progression to neoplasia. This evidence concerns the gene TNF and cervical cancer.