In Iranian patients, haplotypes such as HLA-DRB1*11/-DQB1*03:01/-DQA1*05:05 and HLA-DRB1*04/-DQB1*03:02/-DQA1*03:01 seem to be predisposed to CML [19,20]. This evidence concerns the gene HLA-DRB1 and chronic myelogenous leukemia, BCR-ABL1 positive.