This approach allows us to simulate and compute the ratios of the cumulative sum of five cytokines (IL-10, IL-6, IFN-γ, TGF-β1, and TNFα) and to calculate the Kaplan–Meier failure estimate of patients with CML with favorable and unfavorable treatment outcomes in the course of treatment for up to 12 years. Here, TGFB1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.