Nevertheless, an earlier work suggested that CML mesenchymal stem cell (MSC) overexpressing immunomodulatory factors TGFβ1, IL-6, and IL-10 might contribute to CML immune escape through the activation of myeloid-derived suppressor cells (G-MDSC) [69,74]. The gene discussed is TGFB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.