For example, Zhang and colleagues (2020) derived retinal organoids from two patients with compound heterozygous mutations in the rod–cone dystrophy-causing CRB1 gene (c.1892A>G and c.2548G>A) and identified altered CRB1 splicing patterns that lead to downstream impacts on protein function (producing a truncated protein with reduced function in the core Crumbs complex) [44]. This evidence concerns the gene CRB1 and cone dystrophy.