The ASCL1-positive SCLC (SCLC-A) and NEUROD1-positive SCLC (SCLC-N) subtypes belong to the high NE differentiation group, and the POU2F3-positive SLCL (SCLC-P) and YAP-positive SCLC (SCLC-Y) belong to the low NE differentiation group [110]. This evidence concerns the gene ASCL1 and small cell lung carcinoma.