POU2F3 and small cell lung carcinoma: Gay et al. applied non-negative matrix factorization (NMF) to published data from 81 surgically resected limited-stage (LS)-SCLCs [71] and identified four SCLC subgroups: SCLC-A; SCLC-N; SCLC-P; and a new subtype with low expression of ASLC1, NEUROD1, and POU2F3 transcription factors associated with inflammatory gene signatures called inflamed-SCLC (SCLC-I) [111].