The ASCL1-positive SCLC (SCLC-A) and NEUROD1-positive SCLC (SCLC-N) subtypes belong to the high NE differentiation group, and the POU2F3-positive SLCL (SCLC-P) and YAP-positive SCLC (SCLC-Y) belong to the low NE differentiation group [110]. Here, YAP1 is linked to small cell lung carcinoma.