These homozygous Clpp-KO mice exhibited complete infertility even at an early age, an average weight reduction of up to 70% and length reduction of up to 90% from 12 weeks, impaired locomotor activity by the age of 6 months, sensorineural hearing impairment from 12 to 18 months, and a relative resistance to microbial infections [40]. This evidence concerns the gene CLPP and Infertility.