FMR1 and fragile X syndrome: Individuals with FXS typically enjoy a normal state of health, apart from frequently occurring ear infections in the first few years of life, seizures in 12–15% of cases, and connective tissue issues, such as joint dislocations, hernias and collapsable Eustachian tubes predisposing to otitis media resulting from the absence or insufficiency of FMRP [15].