Very few studies have investigated the impact of mRNA expression of these genes on the survival of BC patients.<h4>Methods</h4>We examined the impact of the mRNA expression of breast cancer gene type 1 (<i>BRCA1</i>), breast cancer gene type 2 (<i>BRCA2</i>), and partner and localizer of <i>BRCA2</i> (<i>PALB2</i>) on the metastasis-free survival (MFS) of patients with early BC using microarray gene expression analysis.<h4>Results</h4>The study was performed in a cohort of 461 patients with a median age of 62 years at initial diagnosis. This evidence concerns the gene BRCA2 and cancer.