Indeed, transitional lymphatic ECs expressing both of their specific markers, lymphatic vessel endothelial hyaluronan receptor-1 and α-SMA, were detected in SSc fibrotic skin, and human dermal lymphatic MVECs cultured in the presence of SSc sera were found to acquire a myofibroblast-like morphofunctional phenotype [43]. Here, LYVE1 is linked to systemic sclerosis.