In this study, OSMRβ expression was reported to be higher in dermal ECs from SSc patients compared to healthy controls, and treatment of healthy dermal MVECs with OSM was able to stimulate the expression of genes and proteins related to EndoMT via OSMRβ and STAT3 signaling pathways, suggesting that the activation of the OSM/OSMRβ axis in ECs could contribute to SSc pathogenesis [36]. This evidence concerns the gene OSMR and systemic sclerosis.