A missense mutation in the ZNF74 gene [rs190749586, P2side = 2.59×10−5,OR=2.77(2.46–3.12)] was associated with both CAD and T2DM, and MTAR analysis validated it at the gene level (PcMTAR=3.78 × 10−5). The gene discussed is ZNF74; the disease is coronary artery disorder.