Currently, there are several clinical trials testing CAR-T cells in AML, mostly targeting CLL1, CD123, and CD33, that are all myeloid antigens overexpressed in leukemic blasts but also in their normal stem cell counterpart; however, various other myeloid antigens (e.g., CD64, CD13, CD93, and CD38) as well as repurposed lymphoid antigens (e.g., CD19, CD7, and CD70) are under investigation. The gene discussed is CLEC12A; the disease is acute myeloid leukemia.