Jin et al. observed a CR/CRi in 7/10 R/R adult AML patients receiving CLL1-directed CAR-T cells after lymphodepletion with cyclophosphamide and fludarabine; six patients experienced high grade CRS while no patient developed CAR-T cell related encephalopathy syndrome (CRES) [70]. The gene discussed is CLEC12A; the disease is acute myeloid leukemia.