Of note, the prevalence of subclinical hypercortisolism was found to be significantly higher in hospitalized patients with T2D compared to controls, with 7% of T2D statistically attributable to subclinical hypercortisolism, and subclinical hypercortisolism was significantly related to severe T2D, defined by the presence of insulin treatment, hypertension, and dyslipidemia [55]. Here, INS is linked to type 2 diabetes mellitus.