CRHR1 and major depressive disorder: We searched within PubMed using the keywords “type 2 diabetes, T2D, major depressive disorder, MDD, depression, stress, hypothalamic-pituitary-adrenal axis, HPA, CRH, CRHR, norepinephrine” and included articles reporting valuable concepts on the association of chronic stress, the CRH system, norepinephrine (NE), depression, and T2D, including the genes CRHR1 and CRHR2.