With severe hypoglycemia, the study controls showed an increase in Angiopoietin 1 (ANGPT1) (<i>p</i> < 0.01) and Dickkopf-1 (DKK1) (<i>p</i> < 0.01), but no changes were seen with mild hypoglycemia. The gene discussed is DKK1; the disease is Hypoglycemia.