ENTPD1 and Insulin resistance: Enjyoji et al. confirmed that the deletion of ENTPD1 led to impaired glucose tolerance associated with hepatic insulin resistance, which, to some extent, supported our findings on ENTPD3 in T2DM [73], since ENTPD3 is structurally and functionally extraordinarily similar to ENTPD1 and is more abundantly expressed in Langerhans’ islets [74].