Using the “FindAllMarkers” function, we found that the CAF-3 subset highly expressed several well-recognized tumor suppressor genes such as SORBS2, HRH2, and MT1M, while displaying a low expression of some extracellular matrix-related genes and potential tumor-promoting genes including COL6A3 and LAMB1, which were different from the other 5 CAF subsets (Figure 7E). Here, HRH2 is linked to neoplasm.