In other cases, WNT pathway initiation is due to mutations in CTNNB1 (more frequently in HCV-related HCC), the inactivation of AXIN1 genes (more frequently in HBV-related HCC) or APC, the aberrant methylation of SOX1 and FZD related proteins, or the acetylation of secreted Frizzled-related proteins [30,59]. This evidence concerns the gene FRZB and hepatocellular carcinoma.