CSCs induce HCC heterogeneity through specific surface marker expression, activating certain pathways of cellular signaling: AKT signaling for CD133+ cells, NF-κB signaling for CD24+ cells, p38 MAPK signaling for EpCAM+ cells, and NF-κB for Triple+ cells [124]. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.