MLKL and ischemia: This study also showed that both cleaved capase-3 and phosphorylated MLKL (mixed lineage kinase domain-like protein), which increased under ischemia/reperfusion, were reduced by VBIT12, suggesting that not only do both apoptosis and necroptosis occur in glaucoma–ischemia models, but that both these processes are mediated by VDAC oligomerization.