Isopentenyl-diphosphate delta-isomerase 1 (IDI1) was the most centric gene of the Louvain community with increased enrichment scores (Figure 4A) involving other cholesterol-related genes such as Squalene Epoxidase (SQLE), Mevalonate Diphosphate Decarboxylase (MVD), Sterol Regulatory Element-Binding Transcription Factor 2 (SREBP2), Farnesyl Diphosphate Synthase (FDPS), and Phosphomevalonate Kinase (PMVK), all of them with increased expression in the HCC of both the LIHC and the LIRI-JP cohorts (Figure 4B,C). Here, SQLE is linked to hepatocellular carcinoma.