In colorectal cancer, the low expression of SPTLC1 leads to worse prognosis [42]; in renal cell carcinoma, it inhibits cell proliferation [43], and in lymphoma patients, a mutation of SPTLC1 increases enzymatic activity, thereby sensitizing BCR-ABL tumors to imatinib [44]. The gene discussed is SPTLC1; the disease is colorectal cancer.