Similarly, cer-pancreatitis induction significantly up-regulated the CHOP levels by 7.3-fold (transcript) and by 2-fold (protein), XBP-1 levels by 3.2-fold (transcript) and by 9.7-fold (protein) and Atf6 by 1.6-fold (transcript) compared to the control (Figure 4A–D). The gene discussed is ATF6; the disease is pancreatitis.