Similar to pancreatitis induction, TM treatment significantly elevated the expression of the PPARγ-PGC1α-FNDC5 pathway (Figure 6); the expressions of PPARγ and PGC1α were significantly elevated under ER stress conditions compared to the control cells (PPARγ transcript and protein expression by 2.5-fold and by 1.4-fold, respectively; PGC1α transcript and protein expression by 2-fold and by 1.7-fold, respectively) (Figure 6A–D). This evidence concerns the gene FNDC5 and pancreatitis.