In contrast, exogenous irisin treatment significantly decreases PPARγ translocation to the nucleus, indicating that exogenous irisin has an inhibitory effect on the PPARγ-PGC1α pathway (Figure 2K,L).Together, our findings demonstrate that cer-pancreatitis treatment significantly up-regulates the PPARγ-PGC1α-FNDC5 pathway, in parallel PL expression and secretion (Figure 1 and Figure 2), while exogenous irisin had an inhibitory effect on PPARγ-PGC1α-FNDC5 and PL. This evidence concerns the gene CBLN1 and pancreatitis.