FNDC5 and pancreatitis: Similarly, IL-6 levels were significantly elevated under cer-pancreatitis by 2.5-fold (transcript) and by 1.7-fold (protein) compared to the control, while the addition of exogenous irisin significantly reduced IL-6 expression levels by 2-fold (transcript) and by 1.4-fold (protein) compared to cer-pancreatitis alone (Figure 3C,D).