Yang et al. demonstrated that cancer-associated fibroblast (CAF)-derived midkine (MK) could induce the upregulation of long non-coding RNA ST7-AS1 in DDP-resistant GC cells, resulting in enhanced phosphorylation of PI3K and AKT and subsequent activation of the PI3K/AKT pathway, thereby facilitating resistance to DDP [106]. This evidence concerns the gene MDK and gastric cancer.