Next, IHC staining in serial sections of HNSCC patients showed that p-MLKL level was negatively correlated with tumor-cell E-cad expression while positively correlated with tumor-cell N-cad expression (Fig. 9C–E), suggesting that extensive necroptosis contributed to HNSCC-cell EMT. This evidence concerns the gene CDH2 and head and neck squamous cell carcinoma.