Inconsistently, although we observed similar upregulation of several conventional DAMPs (e.g., HMGB1, HMGB3 and SNRPA1, etc.), our data showed decreased release of lysosomal and ribosomal components and increased proteasome function in necroptotic HNSCC cells. This evidence concerns the gene HMGB1 and head and neck squamous cell carcinoma.