This present bioinformatics study displayed that the missense genetic variants of TYK2, IFIH1, and COL4A3 genes were associated with T1DM disease. The loss-of-function of TYK2 rs34536443 and decreased level of IFIH1 are known for the protective function of T1DM. This evidence concerns the gene IFIH1 and type 1 diabetes mellitus.