Further, Zheng and collaborators have also found that the miR-22 loading laponite hydrogels inhibit the neointimal formation to reduce the infiltration of the macrophages and reverse the adverse vascular ECM remodeling by the upregulation of miR-22 and downregulation of its target genes methyl-CpG binding protein 2 (MECP2), which may offer a novel strategy to treat cardiovascular diseases (Fig. 7B, C) [211]. This evidence concerns the gene MECP2 and cardiovascular disorder.