With the use of enrichment analysis and correlation analysis of high-through RNA sequencing data, Cen et al. identified has_circ_0057105 as a potential oncogenic regulator targeted to COL1A1 in the activation of EMT in RCC [70], while it was also found to be involved in the process of ferroptosis regulation through target gene VDAC2. This evidence concerns the gene VDAC2 and renal cell carcinoma.