It has also been shown that sry-related HMG-box (Sox)9 plays a crucial role in cancer progression in NSCLC, especially in adenocarcinoma, by inducing a mesenchymal phenotype, promoting cell motility and invasion, and interacting with multiple signaling pathways including neurogenic locus notch homolog protein (Notch), TGF-β, NF-κB, Bone morphogenetic protein (BMP), EGFR, and Wingless/Integrated (Wnt)/β-catenin [98]. This evidence concerns the gene EGFR and adenocarcinoma.