LEUTX and central nervous system neoplasm: In summary, our study expands the knowledge of CIC-rearranged pediatric CNS tumors, specifically those tumors harboring CIC::LEUTX fusions, which may be a heterogeneous group of tumors consisting of CIC-rearranged sarcomas, HGNET CIC fusion-positive, and rare lower-grade neuroepithelial tumors with undefined methylation signatures.