CIC and ganglioglioma: If the methylation result is paradoxical to their morphological or molecular features, as seen in case 2 and case 3 in our cohort, it remains debatable to classify these tumors as ganglioglioma and LGG MYB. However, these cases have demonstrated PFS of 56 and 34 months, respectively, despite their CIC alterations and mild to aggressive morphological appearances.