APOE and early-onset autosomal dominant Alzheimer disease: Furthermore, we examined how they interacted with APOE genotype, as APOE ɛ4 is a well-established risk factor/marker for Alzheimer’s disease (AD) [8] and APOE ɛ2 have been shown both being a risk factor for cardiovascular disease [9] but in a meta-analysis being a protective factor for myocardial infarction [10].