In other studies, such as that of Feng et al. [33], where a heparin-binding epidermal growth factor (HB-EGF) is used as treatment, that of Nakame et al. [34], whose treatment consists of a trophic gut hormone, glucagon-like peptide 2 (GLP-2), and the studies by Tayman et al. [35], Weis et al. [36] and Yarci et al. [37] that we are already familiar with, the tissue with grade 2 or higher NEC damage is evaluated as NEC. This evidence concerns the gene HBEGF and necrotizing enterocolitis.