Other studies on inflammatory bowel diseases have shown that endocannabinoids, thanks to the intestinal endocannabinoid system, are capable of inhibiting extensive pathways that release pro-inflammatory mediators such as Interleukin beta 1 (IL-ß1), multiple cytokines, the well-known TNF-α and nitric oxide, which are ultimately the main causes of these disorders [31, 38, 39]. This evidence concerns the gene IL1B and inflammatory bowel disease.