Furthermore, in a meta-analysis of 86 studies investigating the rates of prescription of vasculoprotective therapies in patients with PAD, the pooled literature estimates for the utilization of antiplatelets, statins, and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers were 75%, 56%, and 53%, respectively, indicating important treatment gaps [107]. Here, ACE is linked to peripheral arterial disease.