The biomolecular characteristics of the surgical sample displayed a locally advanced primitive tumour at stage T4b (pTy4b) with involvement of regional lymph nodes (pNy2a) and absence of distant metastasis (pM0); oestrogen receptor 90%, progesterone receptor < 2%, Ki67 20%, and HER2 1+. After the surgery, the patient was treated with locoregional radiotherapy to the left chest wall and ipsilateral clavicular region (dose of 50.4 Gray in 28 fractions with 3D conformal technique). The gene discussed is PGR; the disease is neoplasm.