GCK and type 2 diabetes mellitus: However, our sensitivity analysis suggested this paradoxical finding could be driven by rs1260326 (GCKR), which encodes glucokinase regulatory protein (GKRP) (a primarily liver-specific protein) and is linked to decreased blood glucose by altering GKRP’s function of suppressing glucokinase activity and enhancing hepatic glycolysis, and concurrently increase total hepatic triglycerides [59], resulting in the risk allele of rs1260326 (T) decreasing the risk of T2D but increasing liver steatosis [30], and impacting the overall analyses.