Increased liver iron was associated with higher risk of liver steatosis (OR: 1.15 per SD, 95% CI: 1.05 to 1.26), liver cirrhosis (OR: 1.34 per SD, 95% CI: 1.07 to 1.68), ALT, and PDFF (Fig. 4B–C; Additional file 1: Tables S15–S16). The gene discussed is GPT; the disease is cirrhosis of liver.