GGT, GPR was able to distinguish cirrhosis (F4) from non-cirrhotic stages (F1-3), while GGT, FIB4 and GPR could distinguish advanced fibrosis (F3-4) from non-advanced fibrosis (F1-2) among individuals with chronic hepatitis B. Finally, Among these biomarkers, GGT was a better biomarker to distinguish cirrhosis (F4) from non-cirrhotic stages (F1-3), while GGT was a better biomarker to identify cirrhosis (F4) from non-cirrhotic stages (F1-3) in patients with chronic hepatitis B. The gene discussed is ALDH18A1; the disease is fibrosis.