FOXP3 and neoplasm: The better outcomes observed in our study could be explained by two proposed concepts: 1: FOXP3 expression may not accurately represent the infiltration of Tregs, as not all Tregs express FOXP3 and not all FOXP3 + cells are Tregs and may have little or no suppressive function [52]; and 2: the infiltration of Tregs may play a role in preventing tumor invasion and metastasis by inhibiting harmful inflammatory processes that benefit tumor growth [26, 47, 52].