FADS1 and cancer: An in-depth metabolic and metabolomic profiling of this ferroptosis-sensitive subset revealed increased intracellular levels of PUFA, particularly PE-linked arachidonic acid and adrenic acid, which are synthesized in cancers with high expression levels of the ELOVL5 (elongation of very long chain fatty acids protein 5) and FADS1 (Lee et al, 2020).