Furthermore, we confirmed the translation expression level of the hub genes using the HPA database, and the prognostic biomarkers were found to be stained strongly or moderately.: SMC4 (Fig. 9A), OCR1 (Fig. 9B), CDCA8 (Fig. 9C), and DLGAP5 (Fig. 9D), indicating that these hub genes were translated more in glioma samples. The gene discussed is SMC4; the disease is central nervous system cancer.