Previous reports have shown that in primary human gastric, brain, breast, colon, liver, and head and neck cancer tissues and tumor cell lines, H3.2 (H3C14), is overexpressed compared to its normal counterparts of different origins; in gastric cancer, EGF-stimulated EGFR increases FOXC1 levels, which enhances H3C14 transcription. Here, EGF is linked to head and neck cancer.