Mutations in the genes encoding the components of the DGC and the DGC ligand laminin α2 give rise to following muscle diseases: Duchenne/Becker muscular dystrophy (dystrophin mutation); limb-girdle muscular dystrophy (LGMD) type 2D, 2E, 2F and 2C (also called sarcoglycanopathies, caused by mutations in α-, β-, δ- and γ-sarcoglycan, respectively) and LAMA2-related muscular dystrophy (LAMA2-RD) (mutations in the laminin α2 chain gene)2,4,5. This evidence concerns the gene LAMA2 and sarcoglycanopathy.