For that purpose, we deleted the Thbs4 gene in β-sarcoglycan knockout mouse (Sgcb KO, the mouse model for LGMD2E), and in a mouse model for LAMA2-RD (laminin α2 chain-deficient dy3K/dy3K mouse). The gene discussed is LAMA2; the disease is autosomal recessive limb-girdle muscular dystrophy type 2E.