The deletion of the Thbs4 gene did not result in an exacerbation of muscular dystrophy in any of these two disorders, indicating that Thbs4 does not have the same disease-modifying effect as has been shown in mice models of Duchenne muscular dystrophy and LGMD2F. The gene discussed is THBS4; the disease is autosomal recessive limb-girdle muscular dystrophy type 2F.