However, these artificial systems do not approach the actual human disease condition e.g., Adnp homozygosity is embryonically lethal1,31 and Helsmoortel-Van der Aa syndrome patients are all unified by heterozygous ADNP mutations13,14, with endogenous ADNP protein expressed at nearly femtomolar concentrations1,17. This evidence concerns the gene ADNP and ADNP-related multiple congenital anomalies-intellectual disability-autism spectrum disorder.