LY6S and neoplasm: Tumour cells showed clear separation of Kmt2c and Kmt2d KO from WT (Fig. 2b), and differential gene expression (DGE) analysis identified Ly6a, Bst2, Ifi27l2a and Stat1 as the top highly upregulated genes in both KO tumour cells compared with the WT (Extended Data Fig. 2c,d and Supplementary Table 2).