APP and Alzheimer disease: Although no formal genetic association has been reported between the PTPRS gene and AD, studies using Ptprs-deficient models of Alzheimer’s pathology revealed that neuronal Ptprs mediates both amyloid and Tau pathogenesis in double transgenic mice by binding to the amyloid precursor protein (APP) and interfering with its binding to the beta-secretase, diminishing the APP proteolytic products generated by the beta- and gamma-secretases24.