Specifically, DiNP-induced asthma significantly (p < 0.05) decreases neural Bcl-2 levels by 64.34% and increases the levels of Cas-3, p53, Bax, K-Ras and c-MYC (57.14, 64.52, 76.19, 23.81 and 53.12% respectively) compared to the control group. The gene discussed is TP53; the disease is asthma.