In order to confirm the association between IFNγ and mitochondrial abnormalities observed in mice, we analyzed bulk RNAseq data from muscle biopsies from 44 DM patients who tested positive for myositis-specific autoantibodies directed against NXP2 (n = 14), TIF1γ (n = 12), Mi2 (n = 12) or MDA5 (n = 6), compared to 33 histologically normal muscle biopsies (NT). Here, MORC3 is linked to myositis disease.