APOE and early-onset autosomal dominant Alzheimer disease: Interestingly, they included genes, such as Lcn2 and Casp3, that are linked to neurotoxicity67,68 as well as others, such as Ralbp1 and Apoe, that are involved in dampening Alzheimer’s disease (AD)-related mitochondrial dysfunction or degradation of amyloid-beta69,70.