Costea et al. found that two subtypes of CAFs, TGF-β-synthesizing fibroblasts (or secretive fibroblasts) and hyaluronan-synthesizing fibroblasts (ECM producing fibroblasts), are both critical for carcinoma invasion as they are responsible for inducing EMT and provide support for tumour cells, respectively [40]. This evidence concerns the gene TGFB1 and neoplasm.