For CD8+ T cells, while no significant differences in OS were observed in FU-iCCA cohort (Supplementary Fig. S2D), the enrichment of intra-tumoral CD8+ T cells correlated with better prognosis in ICC patients from TMA cohort (Fig. 2K and Supplementary Fig. S2E). This evidence concerns the gene CD8A and intrahepatic cholangiocarcinoma.