The American Diabetes Association recommends the measurement of natriuretic peptides (NPs) in patients with type 2 diabetes (T2DM), with use of relatively lower cutoff values of B-type natriuretic peptide (BNP) > 50 pg/mL or N-terminal pro-B-type natriuretic peptide (NT-proBNP) > 125 pg/mL [8]. This evidence concerns the gene NPPB and diabetes mellitus.