For example, the role of nicotinamide phosphoribosyltransferase (NAMPT)-derived NAD+ in the development of skin inflammation (via hyperactivation of PARP1, to result in parthanatos cell death) was illustrated in the context of psoriasis (Martínez-Morcillo et al. 2021) and atopic dermatitis (Arroyo et al. 2023). Here, NAMPT is linked to atopic eczema.