Our analysis revealed that the promoter of INTS6 and INTS9 were hypermethylated in HCC tissues, while the promoter of INTS1, INTS2, INTS5, INTS7, and INTS14 were hypomethylated in HCC tissues compared to normal tissues as shown in Supplementary Fig. 3. Here, INTS5 is linked to hepatocellular carcinoma.