Analysis of the promoter methylation levels of the INTS gene family in HCC tissues revealed hypermethylation of the INTS6 and INTS9 promoters, while the promoters of INTS1, INTS2, INTS5, INTS7, and INTS14 exhibited hypomethylation compared to normal tissues. The gene discussed is INTS1; the disease is hepatocellular carcinoma.