Analysis of the promoter methylation levels of the INTS gene family in HCC tissues revealed hypermethylation of the INTS6 and INTS9 promoters, while the promoters of INTS1, INTS2, INTS5, INTS7, and INTS14 exhibited hypomethylation compared to normal tissues. This evidence concerns the gene INTS5 and hepatocellular carcinoma.