In relation to TP53 mutation status, we investigated the promoter methylations of INTS1, INTS4, INTS7, and INTS8, and only INTS1's promoter methylation coincided with TP53 mutation status, suggesting its involvement in the P53 pathway, which affects HCC progression (Supplementary Fig. 5). This evidence concerns the gene INTS1 and hepatocellular carcinoma.