Moreover, the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed a similar result, including enrichment of signaling pathways such as T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation as well as PD-L1 expression and PD-1 checkpoint pathway in cancer (Supplementary Figure 1A). Here, CD274 is linked to cancer.