More than 150 variants of TTR have been described worldwide and most of them are involved in three TTR-related amyloid diseases (ATTR), namely, familial amyloid cardiomyopathy, familial amyloid polyneuropathy, and a rare form of amyloidosis called oculoleptomeningeal amyloidosis (14, 15, 16). Here, TTR is linked to familial amyloid neuropathy.