NAMPT and neoplasm: NAMPT,also called pre-B-cell colony-enhancing factor 1 (PBEF1) or visfatin,is a rate-limiting enzyme for NAD+ synthesis that playsan important role in tumor generation and progression.30,31 NAMPT is also described as a soluble factor with a cytokine-likeactivity that regulates cell growth, migration, and gene expression.32 Although NAMPT is a promising anticancer drugtarget, its targeting in patients offers a low therapeutic window,with either a lack of antitumor efficacy at lower doses or too manyside effects at higher doses, such as retinal, hematological, or cardiactoxicity.33