In conclusion, our study on the efficacyof the photoactivatedNAMPT inhibitors Ru-STF31 using U87MG cells as an in vitro tumor model has provided valuable insights intothe potential of ruthenium-based PACT treatment of high-grade gliomas.The correlation observed between NAMPT expression and glioma gradingaligns with previous studies, highlighting the view that NAMPT playsa crucial role in glioma aggressiveness. Here, NAMPT is linked to central nervous system cancer.