In conclusion, our study on the efficacyof the photoactivatedNAMPT inhibitors Ru-STF31 using U87MG cells as an in vitro tumor model has provided valuable insights intothe potential of ruthenium-based PACT treatment of high-grade gliomas.The correlation observed between NAMPT expression and glioma gradingaligns with previous studies, highlighting the view that NAMPT playsa crucial role in glioma aggressiveness. The gene discussed is NAMPT; the disease is neoplasm.