Responsive β cells, on the other hand, displayed enrichment in scg2a, an insulin granule–associated gene implicated in β cell function (33, 34); nkx6.2, a transcription involved in β cell specification (47); and tspan7b, a transmembrane protein whose human ortholog represents one of the auto-antigens in T1D (35,36). Here, NKX6-2 is linked to type 1 diabetes mellitus.